As cheesy and dramatic as it sounds, a solid theme like that for the story sounds like a lot of care and effort has been put into Uncharted 4, as it should be. During the interview with OPM Druckmann stated

Clearly Druckmann is giving fans just a bit of insight to keep them hooked and interested in Uncharted 4 as he added s there a way to reconcile that? That’s the message of this game, and everything is constructed around that very simple concept."

This has just been one of many small details revealed about Uncharted 4 that have been released in the past month. Uncharted 4 is going to hit shelves on March 18th, exclusively for PlayStation 4. Naughty Dog has explained why the game was delayed from 2015 to 2016 and although they have stated that Uncharted 4 is the final game starring Drake, they say its hard to imagine the series without Drake. Hopefully Naughty Dog will keep giving us some information that gives fans a clearer picture of what to expect for the next installment in the Uncharted series.

The Emphasis in Uncharted 4 s Story Revealed   Uncharted 4  A Thiefs End - 50